TY - CHAP A1 - Evgeny V. Denisov A2 - Nadezhda V. Cherdyntseva A3 - Nicolay V. Litviakov A4 - Elena A. Malinovskaya A5 - Natalya N. Babyshkina A6 - Valentina A. Belyavskaya A7 - Mikhail I. Voevoda ED1 - Yue Cheng Y1 - 2012-02-03 PY - 2012 T1 - TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities N2 - Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies. BT - Tumor Suppressor Genes SP - Ch. 4 UR - https://doi.org/10.5772/27768 DO - 10.5772/27768 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-10-26 ER -