TY - CHAP A1 - Thian-Sze Wong A2 - Wei Gao A3 - Wai-Kuen Ho A4 - Jimmy Yu-Wai Chan A5 - William Ignace Wei A6 - Raymond King-Yin Tsang ED1 - Xiaoming Li Y1 - 2012-02-03 PY - 2012 T1 - MicroRNA Dysregulation in Squamous Cell Carcinoma of Head and Neck N2 - This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC. BT - Squamous Cell Carcinoma SP - Ch. 15 UR - https://doi.org/10.5772/25376 DO - 10.5772/25376 SN - PB - IntechOpen CY - Rijeka Y2 - 2022-05-28 ER -