TY - CHAP A1 - Xiaoming Li A2 - Qingjia Sun A3 - Yupeng Shen ED1 - Xiaoming Li Y1 - 2012-02-03 PY - 2012 T1 - Molecular Mechanisms Involving Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC) – Roles of Hypoxic Microenvironment and Cancer Stem Cell N2 - This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC. BT - Squamous Cell Carcinoma SP - Ch. 13 UR - https://doi.org/10.5772/25574 DO - 10.5772/25574 SN - PB - IntechOpen CY - Rijeka Y2 - 2022-05-28 ER -