TY - CHAP A1 - J.C.A. Broen A2 - L. McGlynn A3 - T.R.D.J. Radstake A4 - P.G. Shiels ED1 - Timothy Radstake Y1 - 2012-02-03 PY - 2012 T1 - Biological Ageing Research in Systemic Sclerosis: Time to Grow up? N2 - Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting. BT - Systemic Sclerosis SP - Ch. 6 UR - https://doi.org/10.5772/26531 DO - 10.5772/26531 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-12-07 ER -