TY - CHAP A1 - Sébastien Lepreux A2 - Anne Solanilla A3 - Julien Villeneuve A4 - Joël Constans A5 - Alexis Desmoulière A6 - Jean Ripoche ED1 - Timothy Radstake Y1 - 2012-02-03 PY - 2012 T1 - Blood Platelets and Systemic Sclerosis N2 - Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting. BT - Systemic Sclerosis SP - Ch. 2 UR - https://doi.org/10.5772/25866 DO - 10.5772/25866 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-10-01 ER -