TY - CHAP A1 - Daniele Lo Coco A2 - Paolo Volanti A3 - Domenico De Cicco A4 - Antonio Spanevello A5 - Gianluca Battaglia A6 - Santino Marchese A7 - Alfonsa Claudia Taiello A8 - Rossella Spataro A9 - Vincenzo La Bella ED1 - Martin H. Maurer Y1 - 2012-01-20 PY - 2012 T1 - Assessment and Management of Respiratory Dysfunction in Patients with Amyotrophic Lateral Sclerosis N2 - Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research. BT - Amyotrophic Lateral Sclerosis SP - Ch. 25 UR - https://doi.org/10.5772/32377 DO - 10.5772/32377 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-04-07 ER -