TY - CHAP A1 - A. Lejay A2 - A.L. Charles A3 - J. Zoll A4 - J. Bouitbir A5 - F. Thaveau A6 - F. Piquard A7 - B. Geny ED1 - Challa Sundaram Y1 - 2012-01-05 PY - 2012 T1 - Skeletal Muscle Mitochondrial Function in Peripheral Arterial Disease: Usefulness of Muscle Biopsy N2 - Investigation of muscle diseases has changed dramatically with the understanding of genetic basis of a wide range of muscle diseases. Muscle biopsy has become a powerful tool not only to provide diagnosis but to make tissue available for genetic studies and to basic scientists for biomedical research. Accurate interpretation of muscle biopsy to detect cell dysfunction/ damage/death or absence / abnormality of a protein or genetic defect by the sophisticated technologies is important to guide treatment of various muscle diseases. In this book on muscle biopsy various chapters deal with the procedure and interpretation of muscle biopsy, its use in the culture of myotubes and membrane transport studies.Muscle biopsy is an important technique to investigate mitochondrial dysfunction and the mitochondrial DNA integrity in oxidation. Phosphorylation in various metabolic diseases like obesity, type 2 diabetes mellitus and peripheral vascular disease is explored in the other chapters with detailed descriptions on methodology. This book provides the advances in the basic techniques of muscle biopsy for a neuroscientist. BT - Muscle Biopsy SP - Ch. 7 UR - https://doi.org/10.5772/31674 DO - 10.5772/31674 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-09-22 ER -