TY - CHAP A1 - Heike Julia Wobst A2 - Richard Wade-Martins ED1 - Raymond Chuen-Chung Chang Y1 - 2011-12-16 PY - 2011 T1 - From Protein Tangles to Genetic Variants: The Central Role of Tau in Neurodegenerative Disease N2 - Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases. BT - Advanced Understanding of Neurodegenerative Diseases SP - Ch. 11 UR - https://doi.org/10.5772/29839 DO - 10.5772/29839 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-05-08 ER -