TY - CHAP A1 - Chu Xiang-Ping A2 - Wang John Q. A3 - Xiong Zhi-Gang ED1 - Raymond Chuen-Chung Chang Y1 - 2011-12-09 PY - 2011 T1 - Acid-Sensing Ion Channels in Neurodegenerative Diseases: Potential Therapeutic Target N2 - Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases. BT - Neurodegenerative Diseases SP - Ch. 20 UR - https://doi.org/10.5772/28825 DO - 10.5772/28825 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-06 ER -