TY - CHAP A1 - Miriam de Boeck A2 - Peter ten Dijke ED1 - Roxana Sulica ED2 - Ioana Preston Y1 - 2011-12-09 PY - 2011 T1 - Deregulation of BMP Signaling in the Pathogenesis of Pulmonary Hypertension N2 - The textbook "Pulmonary Hypertension - From Bench Research to Clinical Challenges" addresses the following topics: structure and function of the normal pulmonary vasculature; disregulated cellular pathways seen in experimental and human pulmonary hypertension; clinical aspects of pulmonary hypertension in general; presentation of several specific forms of pulmonary hypertension, and management of pulmonary hypertension in special circumstances. The textbook is unique in that it combines pulmonary and cardiac physiology and pathophysiology with clinical aspects of the disease. First two sections are reserved for the basic knowledge and the recent discoveries related to structure and cellular function of the pulmonary vasculature. The chapters also describe disregulated pathways known to be affected in pulmonary hypertension. A special section deals with the effects of hypoxia on the pulmonary vasculature and the myocardium. Other three sections introduce the methods of evaluating pulmonary hypertension to the reader. The chapters present several forms of pulmonary hypertension which are particularly challenging in clinical practice (such as pulmonary arterial hypertension associated with systemic sclerosis), and lastly, they address special considerations regarding management of pulmonary hypertension in certain clinical scenarios such as pulmonary hypertension in the critically ill. BT - Pulmonary Hypertension SP - Ch. 4 UR - https://doi.org/10.5772/26422 DO - 10.5772/26422 SN - PB - IntechOpen CY - Rijeka Y2 - 2018-09-23 ER -