TY - CHAP A1 - Jorge C.G. Blanco A2 - Lioubov M. Pletneva A3 - Lorraine E. Earle A4 - William I. Frels ED1 - Theresa L. Chang Y1 - 2011-11-02 PY - 2011 T1 - The Quest for a Small Animal Model for HIV Infection and Disease N2 - HIV remains the major global health threat, and neither vaccine nor cure is available. Increasing our knowledge on HIV infection will help overcome the challenge of HIV/AIDS. This book covers several aspects of HIV-host interactions in vitro and in vivo. The first section covers the interaction between cellular components and HIV proteins, Integrase, Tat, and Nef. It also discusses the clinical relevance of HIV superinfection. The next two chapters focus on the role of innate immunity including dendritic cells and defensins in HIV infection followed by the section on the impact of host factors on HIV pathogenesis. The section of co-infection includes the impact of Human herpesvirus 6 and Trichomonas vaginalis on HIV infection. The final section focuses on generation of HIV molecular clones that can be used in macaques and the potential use of cotton rats for HIV studies. BT - HIV-Host Interactions SP - Ch. 14 UR - https://doi.org/10.5772/20411 DO - 10.5772/20411 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-19 ER -