TY - CHAP A1 - Carolina Quayle A2 - Carlos Frederico Martins Menck A3 - Keronninn Moreno Lima-Bessa ED1 - Sonya Vengrova Y1 - 2011-10-26 PY - 2011 T1 - Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum N2 - Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers. BT - DNA Repair and Human Health SP - Ch. 6 UR - https://doi.org/10.5772/22946 DO - 10.5772/22946 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-28 ER -