TY - CHAP A1 - Chang-Wen Hsieh A2 - David DeSantis A3 - Colleen M Croniger ED1 - Coleen Croniger Y1 - 2011-09-22 PY - 2011 T1 - Role of Triglyceride/Fatty Acid Cycle in Development of Type 2 Diabetes N2 - Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities. BT - Role of the Adipocyte in Development of Type 2 Diabetes SP - Ch. 3 UR - https://doi.org/10.5772/24033 DO - 10.5772/24033 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-05-12 ER -