TY - CHAP A1 - Valmore Bermúdez A2 - Joselyn Rojas A3 - Miguel Aguirre A4 - Clímaco Cano A5 - Nailet Arraiz A6 - Carlos Silva Paredes A7 - Marcos Lima A8 - Raquel Cano A9 - Eneida Fonseca A10 - Manuel Velasco ED1 - Coleen Croniger Y1 - 2011-09-22 PY - 2011 T1 - The Sick Adipocyte Theory: The Forces of Clustering at Glance N2 - Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities. BT - Role of the Adipocyte in Development of Type 2 Diabetes SP - Ch. 1 UR - https://doi.org/10.5772/20963 DO - 10.5772/20963 SN - PB - IntechOpen CY - Rijeka Y2 - 2022-05-23 ER -