TY - CHAP A1 - Linda C Enns A2 - Warren C Ladiges ED1 - Colleen Croniger Y1 - 2011-09-12 PY - 2011 T1 - Targeting PKA Signaling to Prevent Metabolic Syndrome and Delay Aging N2 - Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed insulin secretion in both healthy individuals and in patients with type 2 diabetes. Because of the risk associated with progression from insulin resistance to diabetes and cardiovascular complications increases along a continuum, we included several chapters on the damage of endothelial cells in type 2 diabetes and genetic influences on endothelial cell dysfunction. Cardiovascular complications occur at a much lower glucose levels, thus a review on the oral glucose tolerance test compared to other methods was included. The medical conditions associated with type 2 diabetes such as pancreatic cancer, sarcopenia and sleep disordered breathing with diabetes were also discussed. The book concludes with several chapters on the treatments for this disease offering us hope in prevention and successful alleviation of the co-morbidities associated with obesity and type 2 diabetes. BT - Medical Complications of Type 2 Diabetes SP - Ch. 17 UR - https://doi.org/10.5772/20898 DO - 10.5772/20898 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-08-04 ER -