TY - CHAP A1 - Kenneth E. Neet A2 - Sidharth Mahapatra A3 - Hrishikesh M. Mehta ED1 - Suzanne De La Monte Y1 - 2011-09-12 PY - 2011 T1 - Selectivity of Cell Signaling in the Neuronal Response Based on NGF Mutations and Peptidomimetics in the Treatment of Alzheimers Disease N2 - Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets. BT - Alzheimer's Disease Pathogenesis SP - Ch. 12 UR - https://doi.org/10.5772/21042 DO - 10.5772/21042 SN - PB - IntechOpen CY - Rijeka Y2 - 2020-09-29 ER -