TY - CHAP A1 - Francisco García-Sierra A2 - Gustavo Basurto-Islas A3 - Jaime Jarero-Basulto A4 - Hugo C. Monroy-Ramírez A5 - Francisco M. Torres Cruz A6 - Hernán Cortés Callejas A7 - Héctor M. Camarillo Rojas A8 - Zdena Kristofikova A9 - Daniela Ripova A10 - José Luna-Muñoz A11 - Raúl Mena A12 - Lester I. Binder A13 - Siddhartha Mondragón-Rodríguez ED1 - Suzanne De La Monte Y1 - 2011-09-12 PY - 2011 T1 - Pathological Stages of Abnormally Processed Tau Protein During Its Aggregation into Fibrillary Structures in Alzheimer’s Disease N2 - Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets. BT - Alzheimer's Disease Pathogenesis SP - Ch. 7 UR - https://doi.org/10.5772/17077 DO - 10.5772/17077 SN - PB - IntechOpen CY - Rijeka Y2 - 2018-09-23 ER -