TY - CHAP A1 - Jun Sakurai A2 - Masataka Oda ED1 - Alexander Vitin Y1 - 2011-08-29 PY - 2011 T1 - Effect of Macrolide Antibiotics on Biological Activities Induced by Clostridium perfringens Alpha-Toxin N2 - Gangrene is the term used to describe the necrosis or death of soft tissue due to obstructed circulation, usually followed by decomposition and putrefaction, a serious, potentially fatal complication. The presented book discusses different aspects of this condition, such as etiology, predisposing factors, demography, pathologic anatomy and mechanisms of development, molecular biology, immunology, microbiology and more. A variety of management strategies, including pharmacological treatment options, surgical and non-surgical solutions and auxiliary methods, are also extensively discussed in the book's chapters. The purpose of the book is not only to provide a reader with an updated information on the discussed problem, but also to give an opportunity for expert opinions exchange and experience sharing. The book contains a collection of 13 articles, contributed by experts, who have conducted a research in the selected area, and also possesses a vast experience in practical management of gangrene and necrosis of different locations. BT - Gangrene SP - Ch. 12 UR - https://doi.org/10.5772/22404 DO - 10.5772/22404 SN - PB - IntechOpen CY - Rijeka Y2 - 2021-09-22 ER -